Twenty years is a very long time — for a relationship or a TV sequence like Gray’s Anatomy. Simply if you assume there’s nothing extra to do, shock!
Followers proceed to tune into Gray’s each season for the most recent medical circumstances, relationship drama, and strong storytelling.
We do not get as a lot Meredith lately, however there’s nonetheless sufficient to fulfill viewers, together with the connection mishaps along with her new love curiosity.
Whereas the present would not have the identical pizzazz and character compatibility because it did within the early years, there’s loads of relationship messiness to entice followers.
However regardless of how nice — or unhealthy — issues get at GSM, some relationships have occurred within the final 20 years that followers will always remember. And some by no means acquired the ending they deserve.
Here’s a listing of our favourite on-screen Gray’s Anatomy ‘ships of all time.
Meredith Gray and Derek Shepherd
The chemistry between Meredith Gray and Derek Shepherd hooked viewers from the primary glimpse and nonetheless captivates twenty years later.
A love like theirs by no means dies, even when one (Derek) does. Their relationship went by means of the worst of ups and downs, like assembly Derek’s spouse (ex).
No different couple has captured that air of eternal love, of being there for one another it doesn’t matter what.
Derek is probably not with Meredith in particular person anymore, however we are able to nonetheless really feel their love years after Derek’s soul left this mortal airplane.
Meredith Gray and Nick Marsh
Followers liked the union between Nick and Meredith from the beginning. Meredith was lastly opening her coronary heart once more years after Derek’s loss of life.
What began as long-distance grew to become a severe ‘ship when Nick joined the employees at Gray Sloan. Whereas Meredith left GSM for a job in Minnesota.
In Season 20, followers adore seeing Nick taking part in the attentive guardian to the children again in Minnesota whereas Mer is again in Seattle at GSM.
Critically, can they ever be in the identical place concurrently?
Derek Shepherd and Addison Montgomery Shepherd
We will not point out Derek’s former relationship with out together with them on this listing. As a result of the 2 docs made an unimaginable pairing to start with.
Earlier than Addison had an affair with Derek’s finest pal Mark. It is her infidelity that pushed Derek to Gray Sloan (Seattle Grace Hospital) and into the arms of Meredith.
Whereas Derek and Addison have been nonetheless married on the time, it was in identify solely.
Viewers had a cut up response on whether or not Derek ought to have labored more durable to maintain his marriage with Addison going or finish the ‘ship to deal with what was growing between him and Meredith.
As soon as a cheater and all that. The Mer-team gained as Derek lastly selected a path.
Addison Montgomery and Mark Sloan
We fell in love with the horny womanizer Mark Sloan from our first assembly, regardless of being a scoundrel for his affair with Addison.
We had much less constructive emotions for Addison, the dishonest spouse.
Regardless of their relationship beginning by means of infidelity, we instantly rooted for them.
If Addie was with Mark, Derek was free to pursue Meredith.
It did not take lengthy to be taught that Mark wasn’t simply Dr. McSteamy, an attractive face and hard-toned physique. He was additionally an excellent, proficient physician and a pleasant man with sturdy relationship potentialities.
We nearly felt sorry for his love-sick emotions. He gave up his life within the metropolis to observe Addi to Seattle.
Regardless of his sacrifices, their relationship withered into nothingness. Nevertheless, everybody stayed good buddies, so there was gentle on the finish of the tunnel.
Mark Sloan and Callie Torres
Mark’s character made him an ideal candidate to be buddies with females like Addison and Callie Torres.
He and Callie began off as a random hookup.
They usually continued to have a sexual association with out the messy feelings of a relationship. Many followers hoped they might develop into extra.
Alas, friendship is all that was there, regardless of having a daughter collectively in later seasons. Their friendship helped Callie understand her bisexuality, getting her on monitor to fulfill the 2 nice loves of her life — each females.
Mark Sloan and Lexie Gray
Poor Mark went by means of the wringer when it comes to relationships. It appeared like he could not catch a break on discovering the fitting lady.
First Addison, then Callie.
Issues appeared to alter when he met the candy and younger Lexie Gray. Sparks flew, as did the tensions and warnings. Their union was forbidden, which made it all of the extra thrilling.
We noticed a special facet to Mark, however his want for a secret relationship wasn’t truthful to Lexi, even when it was for good causes — like maintaining his finest pal from discovering out he was sleeping along with his sister-in-law.
Whereas the eagerness was there, the muse wasn’t. Mark wished youngsters. Lexie did not.
George was a nerdy physician, so nobody was extra shocked than him when the new Callie confirmed curiosity. However she was, as have been we.
However whereas Callie gave the impression to be all in, George was extra reluctant to commit. He proposed on a whim, and they acquired married in Vegas.
However the marriage was a brief one. Callie left George after discovering out about his one-night stand and true emotions for Izzie.
His loss of life hit Callie laborious, leading to her going again to Sloan, paving the way in which for her to have Mark’s child and uncover her twin sexuality.
George O’Malley and Izzie Stevens
The connection between George and Izzie Stevens lasted longer in nuance than it did in actuality. That they had a robust, supportive love, however it was extra of a finest pal who was at all times there for you.
First, George was in love with Izzie however saved quiet. Then when he was married, Izzie determined she liked him too.
After a one-night stand, their relationship tried to take off. Most of us followers weren’t right here for it.
Fortunately, it faltered on the beginning line. They unanimously agreed it wasn’t the fitting time. Sadly, they by no means noticed what may have been earlier than George died heroically.
Izzie Stevens and Denny Duquette
Regardless of the rule towards docs courting their sufferers, Izzie Stevens fell for Denny Duquette, a affected person in want of a coronary heart transplant.
When it appeared like Denny would die earlier than getting a brand new organ, Izzie broke the regulation and her oath to push him up the transplant listing.
Though he acquired a brand new coronary heart and proposed to Izzie, he died of a stroke shortly after she accepted.
His loss of life continued to have an effect on Izzie by means of future ‘ships. His ghost recognized her mind tumor.
Callie Torres and Arizona Robbins
The connection between Callie and Arizona was one in all battle and drama and many on-again, off-again.
As Arizona courted Callie, she concurrently seduced the viewers.
The couple went by means of the ringer, experiencing job adjustments, a disagreement on youngsters, and a airplane crash that killed a number of GSM docs.
Followers knew we have been witnessing a love that might outlast something. Besides we have been fallacious.
The couple had a number of main fights that finally led to a nasty custody battle over Sophia, the daughter Callie shared with Mark.
Most followers hated the way in which their love story ended so brutally merciless. Callie left Gray Sloan to be along with her new girlfriend, Penny, in New York. Arizona adopted later to be near her daughter.
Followers realized they reunited off-screen a couple of years later. Arizona’s look on Gray’s Anatomy Season 20 Episode 4 left followers disillusioned that we did not be taught the place the couple stands.
Callie Torez and Penny Blake
We weren’t positive what to make of Penny Blake when she joined Gray’s. And as soon as she grew to become the physician that killed Derek, we had our minds made up.
So, followers had blended emotions as soon as she and Callie acquired severe. Whereas we wished our lady to be pleased, we weren’t positive it needs to be with Blake. The connection did not keep on display screen so long as others however it had main influence.
When Blake acquired a job throughout the nation, Callie adopted. Sadly, not earlier than followers went by means of numerous drama, just like the custody battle.
Gray’s followers ended up saying goodbye to a different of their favourite docs. Later, it is talked about that the couple broke up a couple of years after the transfer.
Alex Karev and Lexie Gray
Meredith is not the one Gray with relationship issues. Lexie additionally had fairly a time discovering real love.
Poor Lexi can be doomed for heartache if she fell for Alex, since he was in love with another person. (See a development?)
Fortunately, she by no means absolutely invested within the relationship and wasn’t devastated when it fizzled out.
Alex Karev and Izzie Stevens
Izzie and Alex have been buddies earlier than they grew to become lovers. Given their horrible monitor report for relationships — like falling for his or her sufferers — followers had blended emotions when the 2 began having chemistry.
Alone, each docs have been a multitude. However they introduced out the perfect in one another.
The romance allowed the playboy Alex to redeem himself as he proposed to Izzie regardless of considering she was going to die from most cancers.
Though Izzie survived her prognosis, their marriage didn’t. Followers had blended emotions about Alex’s resolution to finish issues after Izzie left however returned for a second likelihood.
Alex Karev and Jo Wilson
Izzie had been good for Alex in some ways, together with serving to him mature into an incredible physician.
So when sparks flew between him and Jo Wilson, followers knew he was lastly prepared for a severe relationship.
Alex and Jo have been two peas in a pod regardless of all of the drama of their relationship stemming from the previous. Once they lastly overcame their hurdles, we have been positive to see a fortunately ever after.
Issues have been excellent till they weren’t. With out warning, Alex left sooner or later to go to his mother. Or so we thought.
Then out of the blue, he is AWOL, no cellphone calls, no correspondence. Full ghosting.
Turned out he discovered his child mamma, Izzie, and selected to stick with her over his present spouse. Delivering the information and divorce papers within the mail? Harsh transfer, Doc!
Jo Wilson and Atticus Lincoln
After two failed marriages, Jo was hesitant to be with anybody else, particularly after adopting daughter Luna.
However who may resist falling for horny surgeon Hyperlink.
At first, they have been simply actually shut buddies, however followers noticed the chemistry.
The buddies grew to become lovers after Hyperlink’s failed relationship with Amelia gave him a son. Whereas elevating their youngsters as single mother and father, emotions grew right into a romantic love.
Season 20 has the 2 in couple mode, and issues appear to be going nicely thus far into the shortened season.
Jackson Avery and April Kepner
Jackson got here onto the scene because the boss’s son and April because the religious Christian.
After Jackson took April’s virginity, most followers anticipated them to remain collectively.
However after a lot pointless backwards and forwards, followers acquired over the redundancy and began to hope for one thing else.
We noticed numerous repeated storylines — April nearly married the fallacious man, she left the nation, she got here again prepared to choose up the place they left off.
Regardless of marriage and shared youngsters, Jackson was unwilling to place within the work, and their union fizzled out.
The couple divorced however later rekindled their ‘ship off-screen when April and their daughter adopted Jackson to Boston.
Jackson Avery and Lexie Gray
Gray’s Anatomy has been a revolving door of shared companions. Followers have seen loads of meant-to-be hookups and simply as many WTF are you considering ‘ships.
After Jackson and April cut up up and Lexie dumped Mark, issues began to warmth up for the 2 newly single docs.
The connection between Lexie and Jackson was primal and purely bodily, as each individuals have been nonetheless in love with their “one.”
It was clear from the start that they have been utilizing one another as an escape.
So it did not shock anybody when Jackson dumped Lexie resulting from nonetheless being in love with Mark.
Cristina Yang and Preston Burke
Cristina was everybody’s favourite good, egotistical surgeon, and Burke was the right mentor. Their coupling cut up followers.
The connection appeared inappropriate for a lot of as a result of Burke was Cristina’s boss.
Though there have been challenges, such because the distinction in job title and non secular beliefs, the couple stayed collectively till their wedding ceremony day.
Owen Hunt got here to Gray Sloan in a flurry of motion and physician brilliance.
It is no surprise his distinctive method of medical therapy caught the attention of Yang.
Their courtship was messy and appeared like it might finish a number of occasions, however they ended up married as a substitute.
Though there was lots that ought to have saved them aside.
A number of elements labored, like nails in a coffin, to lastly finish their marriage. They initially divorced for the lawsuit after the airplane crash.
From our first introduction, Amelia was a multitude. Though Derek’s sister, followers didn’t see a lot household resemblance.
Each docs had a tough previous, with loads of demons nonetheless haunting them. Hunt had PTSD from his time at struggle.
Amelia was a drug addict with a mind tumor that triggered irrational conduct.
Distress loves firm, so nobody felt stunned when the couple tied the knot. Simply as the wedding started, the couple argued about having youngsters, which led to an amicable divorce.
Followers watched in horror as they determined to attempt their relationship once more after the mind tumor was gone.
However earlier than we needed to get on board with spherical 2, they skilled a remaining blowout that led to the tip of their coupling.
Amelia Shepherd and Atticus Hyperlink
After the failed ‘ship between Amelia and Owen, there was the opportunity of Amelia with Hyperlink.
Followers have been in love with the gorgeous boy surgeon who gave Amelia all the eye and understanding she did not get with Owen.
He went to bat for her and followers weren’t the one ones to understand his help.
The couple began as buddies, grew into lovers, had a baby collectively, and cut up up. However regardless of their division, the couple are wonderful at co-parenting.
Owen Hunt and Teddy Altman
Teddy and Owen return pre-hospital to after they labored collectively abroad as Military surgeons.
Regardless of having emotions for one another within the desert, they begin with a platonic relationship as soon as Teddy involves Seattle Grace.
The couple lastly acquired their likelihood collectively after Owen went by means of a number of failed relationships, together with with Cristina and Amelia.
Issues have been rocky from day 1 as Teddy struggled to be the backup. It wasn’t till she acquired pregnant that she was able to attempt with Owen.
Who was nonetheless with Amelia.
After the delivery of their daughter, Owen lastly proposed to Teddy, who was in one other relationship on the identical time.
The couple are nonetheless married — though there’s usually drama — in Season 20.
Miranda Bailey and Ben Warren
Miranda’s massive character and brilliance made everybody fall in love along with her, together with then-anesthesiologist Ben Warren — now a firefighter at Station 19.
After Bailey’s catastrophe of a wedding to her first husband Tuck, followers swooned over the extreme wooing Ben did to seize her consideration.
All the things in regards to the man appeared excellent, which solely appeared to work towards him as Bailey resisted his advances.
Followers are thrilled to see that her disinterest did not final lengthy.
Their love story is the epitome of what we predict an ideal marriage needs to be, even years later when most different relationships have fallen to the wayside.
Richard Webber and Catherine Fox
The early seasons of Gray’s Anatomy revealed the historical past between Richard and Meredith’s mom, efficiently laying the muse for the complete sequence.
After the emotional ordeal of Richard’s first marriage, followers have been glad to see him get a second likelihood at love.
Nobody anticipated extra heartache within the works as his new love, Catherine, acquired sick too.
The person critically cannot catch a break! It is no surprise he struggles with alcohol.
As of Season 20, followers are glad to see the wedding nonetheless going sturdy and maintain out hope that Catherine’s present well being prognosis continues to remain constructive.
Levi Schmitt and Nico Kim
Levi made fairly the impression as a surgical resident. Since his nerdy fumbling as a primary yr, he is develop into fairly the physician. Even when his love life hasn’t labored out as nicely.
Followers cheered in delight when Levi lastly discovered somebody to assist him discover his sexuality. Nico was the right first, however followers by no means anticipated it to be Levi’s solely.
Sadly, their relationship did not final, however nobody ever forgets their first. Particularly when it is as life-changing as realizing you are homosexual.
Many followers hoped that Nico would return and the couple may begin once more.
It broke poor Levi’s coronary heart, however followers hope it was the closure he wanted to lastly transfer on and discover his real love.
Maggie Pierce and Winston Ndugu
Maggie’s arrival at GSM triggered fairly a stir since Meredith was unaware she had one other sister.
And Richard was simply as shocked to seek out out he had a daughter.
Maggie had a couple of relationships earlier than Winston, together with Andrew DeLucas and a short dalliance with Jackson Avery (whose mother was married to her dad).
Originally of their relationship, Maggie and Winston lived lengthy distance. She lived in Seattle, and he was in Boston.
After COVID, Winston relocated to Seattle to work at Gray Sloan, and the couple acquired engaged.
Issues appeared to maneuver quick for them and the followers, leaving a lot to be desired. When the issues began, we barely had time to regulate to the wedding.
Sadly, followers stated goodbye to Maggie and the union in Season 19. The divorce papers delivered to Winston in Season 20 gave us a much-needed, if awkward, decision.
Simone Griffith and Lucas Adams
Simone and Lucas are two of the most recent residents to affix the ranks of Gray’s. Followers have paralleled their love story and that of Derek and Mer.
It is no shock, given Lucas’s DNA. He’s Derek’s nephew, in spite of everything. He has greatness in his genes.
Lucas has been in love with Simone since they met.
And Simone was engaged to another person. The marriage nearly occurred, however Simone referred to as it off on the final minute.
Nobody, together with the couple, appears to know the place they stand. If issues can work out, we would have our subsequent real love story.
What do you consider this listing of the best relationships on Gray’s Anatomy? Is there a relationship we did not embody that you just like?
Be sure you remark along with your choose for the perfect couple.
Sara Trimble is a employees author for TV Fanatic. You may observe her on X.
